FITC标记的膜内蛋白酶5抗体
产品名称： FITC标记的膜内蛋白酶5抗体
英文名称： Anti-IMP5/FITC
产品编号： HZ-16622R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-IMP5/FITC Conjugated antibody
FITC标记的膜内蛋白酶5抗体
| 英文名称 | Anti-IMP5/FITC |
| 中文名称 | FITC标记的膜内蛋白酶5抗体 |
| 别 名 | IMP-5; SPP2C_HUMAN; Intramembrane protease 5; Signal peptide peptidase-like 2C; SPP-like 2C; SPPL2c; SPPL2C. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 泛素 细胞膜蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 72kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IMP5 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Intramembrane proteolysis is now widely recognized as an important physiological pathway required for reverse signaling and membrane protein degradation. Aspartyl intramembrane cleaving proteases of the GXGD-type play an important regulatory role in health and disease. Signal peptide peptidase (SPP) and SPP-like (SPPL) peptidases, such as SPPL2a, SPPL2b, IMP5, and SPPL3, belong to the family of GXGD aspartic proteases. The putative catalytic domains of SPP and SPPLs are embedded in membranes in an orientation predisposed to cleave type II oriented transmembrane proteins. IMP5 (intramembrane protease 5), also known as SPPL2c (signal peptide peptidase-like 2C), is a 690 amino acid multi-pass membrane protein that may act as an intramembrane protease. IMP5 also belongs to the peptidase A22B family and two isoforms are produced by alternative splicing events. Function: May act as intramembrane protease. Subcellular Location: Membrane. Similarity: Belongs to the peptidase A22B family. Database links: Entrez Gene: 162540 Human Omim: 608284 Human SwissProt: Q8IUH8 Human Unigene: 144491 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
膜内蛋白水解是目前公认的反向信号转导和膜蛋白降解的重要生理途径。GXGD型天冬氨酸膜内裂解蛋白酶在健康和疾病中起着重要的调节作用。信号肽肽酶（SPP）和类SPP（SPPL）肽酶，如SPPL2a、SPPL2b、IMP5和SPL3，属于GXGD天冬氨酸蛋白酶家族。SPP和SPL的假定催化结构域以易于裂解II型跨膜蛋白的方向嵌入膜中。IMP5（膜内蛋白酶5），也称为SPPL2c（信号肽肽肽酶样2C），是一种690个氨基酸的多路膜蛋白，可以作为膜内蛋白酶。IMP5也属于肽酶A22B家族，两个异构体由选择性剪接事件产生。