SMURF1,Smad蛋白E3泛素连接酶1抗体

产品编号HZ-9391R
英文名称SMURF1
中文名称Smad蛋白E3泛素连接酶1抗体
别 名Smad ubiquitination regulatory factor 1; Smad ubiquitination regulatory factor 1; Smad specific E3 ubiquitin ligase 1; E3 ubiquitin-protein ligase SMURF1; hSMURF1; Smad specific E3 ubiquitin ligase 1; SMAD specific E3 ubiquitin protein ligase 1; Smad ubiquitination regulatory factor 1; SMAD-specific E3 ubiquitin-protein ligase 1; SMUF1_HUMAN; SMURF 1; smurf1.
说 明 书0.1ml 0.2ml
研究领域细胞生物 细胞周期蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse,
SMURF1,Smad蛋白E3泛素连接酶1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量83kDa
细胞定位细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human SMURF1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
SMURF1,Smad蛋白E3泛素连接酶1抗体PubMedPubMed
产品介绍background:
E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Acts by mediating ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members.

Subcellular Location:
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Similarity:
Contains 1 C2 domain.
Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
Contains 2 WW domains.

Gene ID:
75154

Database links:
Entrez Gene: 57154 Human
Entrez Gene: 75788 Mouse
Omim: 605568 Human
SwissProt: Q9HCE7 Human
SwissProt: Q9CUN6 Mouse
Unigene: 189329 Human
Unigene: 27735 Mouse

SMURF1,Smad蛋白E3泛素连接酶1抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.