FITC标记的乳腺癌、胃癌抗原GA55抗体
产品名称： FITC标记的乳腺癌、胃癌抗原GA55抗体
英文名称： Anti-TACC1/FITC
产品编号： HZ-7939R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-TACC1/FITC Conjugated antibody
FITC标记的乳腺癌、胃癌抗原GA55抗体
| 英文名称 | Anti-TACC1/FITC |
| 中文名称 | FITC标记的乳腺癌、胃癌抗原GA55抗体 |
| 别 名 | Ga 55; Ga55; Gastric cancer antigen Ga 55; Gastric cancer antigen Ga55; KIAA1103; TACC 1; Taxin 1; Taxin1; transforming acidic coiled coil containing protein 1; DKFZp686K18126; TACC1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 细胞周期蛋白 细胞分化 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 90kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TACC1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: TACC1 is one of three TACC family members, which are thought to be involved in breast tumorigenesis. TACC1 is located on 8p11 chromosomal region that is amplified in approximately 15% of all breast tumor samples. The short arm of chromosome 8 also contains FGFR1 whose expression is enhanced in most breast cancer tumors. TACC family members, TACC1, TACC2, and TACC3, map very closely to the corresponding FGFR1, FGFR2, FGFR3 genes on chromosomes 8, 10, and 4. Subsequently, since they are phylogenetically related, it is proposed that TACC and FGFR have similar roles in cell growth and differentiation. Also, TACC1 contains a conserved C-terminal region as in the Drosophila homolog, D-TACC. It has been shown that D-TACC is necessary for normal spindle function, and the mammalian TACC proteins appears to interact with centrosomes and microtubules in a similar manner Subunit: Interacts with KIAA0097/CH-TOG and with the oncogenic transcription factor YEATS4. Interacts with AURKA, AURKB and AURKC. Interacts with LSM7, TDRD7 and SNRPG. Interacts with GCN5L2 and PCAF. Subcellular Location: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, centrosome. Note=Nucleus during interphase. Weakly concentrated at centrosomes during mitosis and colocalizes with AURKC at the midbody during cytokinesis. Tissue Specificity: Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues. Down-regulated in a subset of cases of breast cancer. Similarity: Belongs to the TACC family. Contains 2 SPAZ (Ser/Pro-rich AZU-1) domains. Database links: UniProtKB/Swiss-Prot: O75410.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
TACC1是三个TACC家族成员之一，被认为参与了乳腺肿瘤的发生。TACC1位于8p11染色体区域，在所有乳腺肿瘤样本中扩增约15%。染色体8的短臂也含有FGFR1，其在大多数乳腺癌肿瘤中的表达增强。TACC家族成员TACC1、TACC2和TACC3与染色体8, 10和4上的FGFR1、FGFR2、FGFR3基因非常接近。随后，由于它们是系统发育相关的，因此建议TACC和FGFR在细胞生长和分化中具有相似的作用。此外，TACC1包含保守的C-末端区域，如果蝇同源物，D-TACC。已经证明，D- TACC对于正常的纺锤体功能是必需的，哺乳动物TACC蛋白似乎以类似的方式与中心体和微管相互作用。