FITC标记的FAS凋亡抑制分子1抗体
产品名称： FITC标记的FAS凋亡抑制分子1抗体
英文名称： Anti-FAIM1/FITC
产品编号： HZ-7061R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-FAIM1/FITC Conjugated antibody
FITC标记的FAS凋亡抑制分子1抗体
| 英文名称 | Anti-FAIM1/FITC |
| 中文名称 | FITC标记的FAS凋亡抑制分子1抗体 |
| 别 名 | FAIM 1; FAIM; Fas apoptotic inhibitory molecule 1; Fas apoptotic inhibitory molecule; FAIM1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 细胞凋亡 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, Zebrafish |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 20kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FAIM1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: FAIM1 (or Fas Apoptotic Inhibitory Molecule 1) is a recently discovered negative regulator of apoptosis. FAIM1 has no significant regions of homology to other gene products that modulate Fas killing. It plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells. Overexpression of FAIM1 diminishes sensitivity to Fas mediated apoptosis of B and non B cell lines. FAIM1 is highly evolutionarily conserved and is widely expressed in murine tissues, suggesting that FAIM1 plays an important role in cellular physiology. Function: Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells (By similarity). Subcellular Location: Cytoplasm (By similarity). Similarity: Belongs to the FAIM1 family. Database links: Entrez Gene: 55179 Human Entrez Gene: 23873 Mouse Entrez Gene: 100362113 Rat Entrez Gene: 140930 Rat SwissProt: Q9NVQ4 Human SwissProt: Q9WUD8 Mouse SwissProt: Q8R5H8 Rat Unigene: 173438 Human Unigene: 74605 Mouse Unigene: 106419 Rat Unigene: 199757 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
FAIM1（或Fas凋亡抑制分子1）是最近发现的凋亡负调控因子。FAIM1与调节Fas杀灭的其它基因产物没有明显的同源性。它作为一种诱导性效应分子发挥作用，介导了表面Ig参与B细胞产生的Fas抗性。FAIM1的过度表达降低了对Fas介导的B细胞和非B细胞系凋亡的敏感性。FAIM1是高度进化保守的，在小鼠组织中广泛表达，提示FAIM1在细胞生理中起着重要作用。