FITC标记的细胞因子信号传导抑制蛋白6抗体
产品名称： FITC标记的细胞因子信号传导抑制蛋白6抗体
英文名称： Anti-SOCS6/FITC
产品编号： HZ-10685R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-SOCS6/FITC Conjugated antibody
FITC标记的细胞因子信号传导抑制蛋白6抗体
| 英文名称 | Anti-SOCS6/FITC |
| 中文名称 | FITC标记的细胞因子信号传导抑制蛋白6抗体 |
| 别 名 | CIS-4; CIS4; Cish4; Cytokine inducible SH2 protein 4; Cytokine-inducible SH2 protein 4; HSPC060; SOCS-4; SOCS-6; SOCS4; Socs6; SOCS6_HUMAN; SSI4; STAI4; STAT induced STAT inhibitor 4; STAT4; STATI4; Suppressor of cytokine signaling 4; Suppressor of cytokine signaling 6. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 59kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SOCS6 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008]. Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor. Subunit: Interacts with RBCK1. Interacts with phosphorylated IRS4. Interacts with PIM3. Interacts with KIT (phosphorylated). Similarity: Contains 1 SH2 domain. Contains 1 SOCS box domain. Database links: Entrez Gene: 9306 Human Entrez Gene: 54607 Mouse Omim: 605118 Human SwissProt: O14544 Human SwissProt: Q9JLY0 Mouse Unigene: 44439 Human Unigene: 476577 Mouse Unigene: 91920 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因编码的蛋白含有SH2结构域和顺式同源结构域。因此，该蛋白属于细胞因子诱导的STAT抑制剂(CIS)，也称为细胞因子信号转导的抑制剂(SOCS)或STAT诱导的STAT抑制剂(SSI)，蛋白家族。CIS家族成员被认为是细胞因子诱导的细胞因子信号负调控因子。GM-CSF和EPO在造血细胞中可诱导该基因的表达。该基因在非因子依赖性慢性粒细胞白血病（CML）和红细胞白血病（HEL）细胞系中高表达。[ RefSeq，JUL 2008 ]提供。