FMNL1,成蛋白相关蛋白1抗体

产品编号HZ-6812R
英文名称FMNL1
中文名称成蛋白相关蛋白1抗体
别 名C17orf1; C17orf1B; CLL associated antigen KW 13; FHOD4; FMNL; Fnrl; Formin like 1; Formin like; Formin related protein; Frls; KW 13; KW13; Leukocyte formin; MGC133052; MGC1894; MGC21878; FMNL_HUMAN.
说 明 书0.1ml 0.2ml
研究领域肿瘤 免疫学 肿瘤细胞生物标志物
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep,
FMNL1,成蛋白相关蛋白1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量122kDa
细胞定位细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human FMNL1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
FMNL1,成蛋白相关蛋白1抗体PubMedPubMed
产品介绍background:
FMNL1 (Formin-like protein 1) gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cyokinesis, and cell polarity. An alternative splice variant has been described but the full length sequence has not yet been determined. FMNL1 possibly has a role in the control of cell motility and survival of macrophages.

Function:
May play a role in the control of cell motility and survival of macrophages. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape.

Subunit:
Interacts with RAC1, PFN1 and PFN2.Interacts (activated by RAC1) with SRGAP2 (via SH3 domain); regulates the actin filament severing activity of FMNL1.

FMNL1,成蛋白相关蛋白1抗体Subcellular Location:
Cytoplasm. Cell membrane; Lipid-anchor. Cytoplasmic vesicle, phagosome. Note=Recruited to actin-rich phagosomes during phagocytosis. Translocates to the plasma membrane upon activation by RAC1.
Isoform 3: Cytoplasm, cell cortex. Cell projection, bleb. Note=Colocalized with F-actin in bleb protrusions.

Tissue Specificity:
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Post-translational modifications:
Myristoylation mediates membrane localization and blebbing.

Similarity:
Belongs to the formin homology family.
Contains 1 DAD (diaphanous autoregulatory) domain.
Contains 1 FH2 (formin homology 2) domain.
Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.

Gene ID:
752

FMNL1,成蛋白相关蛋白1抗体Database links:
Entrez Gene: 752 Human
Entrez Gene: 57778 Mouse
Entrez Gene: 287746 Rat
Omim: 604656 Human
SwissProt: O95466 Human
SwissProt: Q9JL26 Mouse
Unigene: 100217 Human
Unigene: 138913 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.