FITC标记的乙酰辅酶A羧化酶抗体
产品名称： FITC标记的乙酰辅酶A羧化酶抗体
英文名称： Anti-Acetyl Coenzyme A Carboxylase/FITC
产品编号： HZ-2745R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： Flow-Cyt=1:50-200 IF=1:50-200
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Rabbit Anti-Acetyl Coenzyme A Carboxylase/FITC Conjugated antibody
FITC标记的乙酰辅酶A羧化酶抗体
| 英文名称 | Anti-Acetyl Coenzyme A Carboxylase/FITC |
| 中文名称 | FITC标记的乙酰辅酶A羧化酶抗体 |
| 别 名 | Acetyl Coenzyme A Carboxylase; ACAS2; AceCS; Acetate CoA ligase; Acetyl CoA synthetase; Acetyl coenzyme A synthetase cytoplasmic; Acetyl-CoA synthetase; ACS; ACSA; ACSS2; Acyl activating enzyme; Acyl CoA synthetase short chain family member 2; EC 6.2.1.1; MYH7B; ACAC; ACACB; ACC alpha; ACC beta; ACC1; ACC2; ACCA; ACCB; Acetyl CoA carboxylase 1; Acetyl CoA carboxylase 2; Acetyl CoA carboxylase alpha; Acetyl CoA carboxylase beta; Biotin carboxylase; COA1; COA2; HFA1; ACACB_HUMAN; ACACA_HUMAN; Acetyl Coenzyme A Carboxylase; Acetyl-CoA carboxylase 1; ACC1; ACC-alpha; Acetyl-CoA carboxylase 265; ACC-alpha; ACC-beta. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Cow, Monkey, |
| 产品应用 | Flow-Cyt=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 265kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Acetyl Coenzyme A Carboxylase 1/2 (2307-2355aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Function: ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Subunit: Monomer, homodimer, and homotetramer. Can form filamentous polymers. Interacts with MID1IP1; interaction with MID1IP1 promotes oligomerization and increases its activity. Subcellular Location: Endomembrane system. Note=May associate with membranes. Tissue Specificity: Predominantly expressed in the heart, skeletal muscles and liver. Similarity: Contains 1 ATP-grasp domain. Contains 1 biotin carboxylation domain. Contains 1 biotinyl-binding domain. Contains 1 carboxyltransferase domain. Database links: Entrez Gene: 31 Human Entrez Gene: 32 Human Entrez Gene: 100705 Mouse Entrez Gene: 107476 Mouse Entrez Gene: 116719 Rat Entrez Gene: 60581 Rat Omim: 200350 Human Omim: 601557 Human SwissProt: O00763 Human SwissProt: Q13085 Human SwissProt: Q5SWU9 Mouse SwissProt: O70151 Rat SwissProt: P11497 Rat Unigene: 160556 Human Unigene: 234898 Human Unigene: 44372 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Acetyl CoA carboxylase（ACC）是一种复杂的多功能酶系统。ACC是一种含生物素的酶，它催化乙酰辅酶A羧化为丙二酰辅酶A，这是脂肪酸合成中的限速步骤。有两种ACC形式，α和β，由两种不同的基因编码。ACCα在脂肪组织中高度富集。该酶长期处于转录和翻译水平，并在短期调控下通过靶向丝氨酸残基的磷酸化/去磷酸化和柠檬酸盐或棕榈酰辅酶A的变构转化。在该基因中发现了多个交替编码的转录变体，在5’序列中发散并编码不同的亚型。[ RefSeq，JUL 2008 ]提供。