FITC标记的同源盒基因HOXA4蛋白抗体
产品名称： FITC标记的同源盒基因HOXA4蛋白抗体
英文名称： Anti-HOXA4/FITC
产品编号： HZ-11293R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-HOXA4/FITC Conjugated antibody
FITC标记的同源盒基因HOXA4蛋白抗体
| 产品编号 | bs-11293R-FITC |
| 英文名称 | Anti-HOXA4/FITC |
| 中文名称 | FITC标记的同源盒基因HOXA4蛋白抗体 |
| 别 名 | Dfd like protein; Homeo box A4; Homeobox A4; Homeobox protein Hox-1.4; Homeobox protein Hox-1D; Homeobox protein Hox-A4; Hox 1.4 like protein; hox-1.4; hox-1d; HOX1; HOX1D; HOXA4; HXA4_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 34kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human HOXA4 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The Hox homeobox genes encode proteins that are transcriptional regulators with an established role in embryonic development. HoxA4 (homeobox A4), also known as HOX1D or HOX1, is a 320 amino acid protein that localizes to the nucleus and contains one homeobox DNA-binding domain. Expressed in the embryonic nervous system, HoxA4 functions as a sequence-specific DNA-binding transcription factor that is part of a regulatory mechanism that provides cells with positional identities during development. Via its ability to bind DNA, HoxA4 plays an important role in the regulation of gene expression, as well as morphogenesis and differentiation. The gene encoding HoxA4 maps to human chromosome 7, which houses over 1,000 genes and comprises nearly 5% of the human genome. Defects in some of the genes localized to chromosome 7 have been linked to Osteogenesis imperfecta, Williams-Beuren syndrome, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome. Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5'-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT-3'. Subcellular Location: Nucleus. Tissue Specificity: Embryonic nervous system. Similarity: Belongs to the Antp homeobox family. Deformed subfamily. Contains 1 homeobox DNA-binding domain. Database links: UniProtKB/Swiss-Prot: Q00056.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Hox同源框基因编码的蛋白是转录调控因子，在胚胎发育中起着重要作用。HOXA4（同源盒A4），也称为HOX1D或HOX1，是一种320个氨基酸的蛋白质，定位于细胞核并含有一个同源盒DNA结合结构域。在胚胎神经系统中表达，HOXA4起到序列特异性DNA结合转录因子的作用，这是在发育过程中为细胞提供位置身份的调节机制的一部分。HOXA4通过其结合DNA的能力在基因表达调控、形态发生和分化中起着重要的作用。编码HOXA4的基因映射到人类7号染色体，该基因含有1000个以上的基因，并包含人类基因组的近5%。局限于7号染色体的一些基因的缺陷与成骨不全、威廉姆斯-伯伦综合征、彭德雷氏综合征、Lissencephaly、瓜氨酸血症和SuWakman钻石综合征有关。