FITC标记的载脂蛋白B-mRNA编辑酶复合物3C抗体
产品名称： FITC标记的载脂蛋白B-mRNA编辑酶复合物3C抗体
英文名称： Anti-APOBEC3C/FITC
产品编号： HZ-12495R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-APOBEC3C/FITC Conjugated antibody
FITC标记的载脂蛋白B-mRNA编辑酶复合物3C抗体
| 英文名称 | Anti-APOBEC3C/FITC |
| 中文名称 | FITC标记的载脂蛋白B-mRNA编辑酶复合物3C抗体 |
| 别 名 | ABC3C_HUMAN; APOBEC1 like; APOBEC1-like; APOBEC1L; APOBEC3C; Apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3C; ARDC2; ARDC4; ARP5; bK150C2.3; MGC19485; PBI; Phorbolin I; Phorbolin I protein; Probable DNA dC dU editing enzyme APOBEC 3C; Probable DNA dC->dU-editing enzyme APOBEC-3C. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 23kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human APOBEC3C |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: APOBEC proteins inhibit retroviruses by deaminating cytosine residues of viral RNA and DNA. The seven APOBEC3 genes or pseudogenes are found in a cluster thought to result from gene duplication on chromosome 22. Like APOBEC3G, APOBEC3F deaminates deoxycytosine to deoxyuracil in the minus strand of HIV-1 DNA, resulting in G to A hypermutation in the plus strand of DNA. Thus, APOBEC3G and APOBEC3F provide a mechanism for innate immunity to retroviruses, and are also likely contribute to sequence variation observed in many viruses. Viral infectivity factor (Vif) imparts APOBEC3G and APOBEC3F resistance to HIV through impaired translation of their mRNA and accelerated posttranslational degradation of the APOBEC3 proteins by the 26S proteasome. Interestingly, HIV-1 Vif cannot form a complex with APOBEC3G or APOBEC3F of mouse origin as it does with the human protein, and thus mouse APOBEC3G and APOBEC3F function as a potent inhibitors of wildtype HIV-1 replication, where human APOBEC3G and APOBEC3F are only able to inhibit Vif-deficient HIV-1 replication. This implies that induction of APOBEC3G and APOBEC3F activity or a method of blocking their interaction with Vif may provide a method for therapeutic intervention. Function: Host cellular restriction factor that may have antiviral activities against exogenous and endogenous viruses, as well as retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. Subunit: Homodimer. Interacts with human foamy virus protein Bet; this interaction does not induce APOBEC3C degradation, but prevents dimerization and incorporation into virion of the latter. Interacts with TRIB3 and EIF2C2/AGO2. Subcellular Location: Nucleus. Cytoplasm. Tissue Specificity: Expressed in spleen, testes, peripherical blood lymphocytes, heart, thymus, prostate and ovary. Similarity: Belongs to the cytidine and deoxycytidylate deaminase family. Database links: Entrez Gene: 27350 Human Omim: 607750 Human SwissProt: Q9NRW3 Human Unigene: 441124 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
ApOBEC蛋白通过脱毒病毒RNA和DNA胞嘧啶残基抑制逆转录病毒。七个ApObEC3基因或假基因存在于由22号染色体上的基因复制导致的集群中。与APOBEC3G类似，APOBEC3F在HIV-1DNA负链中脱氧胞嘧啶脱氨为脱氧尿嘧啶，导致正链DNA的G到A超突变。因此，APOBEC3G和APBEC3F提供了对逆转录病毒先天免疫的机制，并且还可能有助于在许多病毒中观察到的序列变化。病毒感染因子（Vif）通过APOBEC3G和APBEC3FmRNA翻译受损以及APOBEC3蛋白被26S蛋白酶体翻译后降解加速，赋予APOBEC3G和APBEC3F对HIV的抗性。有趣的是，HIV-1 Vif不能像与人类蛋白那样与小鼠来源的APOEC3G或APOBEC3F形成复合物，因此小鼠APOBEC3G和APOEC3F作为野生型HIV-1复制的有效抑制剂发挥作用，其中人APOBEC3G和APOEC3F只能抑制Vif缺乏的HI。V-1复制。这意味着APOBEC3G和APBEC3F活性的诱导或阻断其与Vif相互作用的方法可以提供治疗干预的方法。