FITC标记的FBXL18蛋白抗体
产品名称： FITC标记的FBXL18蛋白抗体
英文名称： Anti-FBXL18/FITC
产品编号： HZ-16039R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749 点击查看
- 传真 : 点击查看
- 邮箱 : www.shzbio.net
- 二维码 : 点击查看
Rabbit Anti-FBXL18/FITC Conjugated antibody
FITC标记的FBXL18蛋白抗体
| 文名称 | Anti-FBXL18/FITC |
| 中文名称 | FITC标记的FBXL18蛋白抗体 |
| 别 名 | F box and leucine rich repeat protein 18; F box/LRR repeat protein 18; FBL18; FBXL 18; FXL18_HUMAN; FLJ10776; FLJ11467; FLJ26934; FLJ38075; FLJ41541. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 88kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FBXL18 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: FBL18 (F-box and leucine-rich repeat protein 18), also known as FBXL18, is an 805 amino acid protein that contains an F-box near its N-terminus, followed by several leucine-rich repeats and a transmembrane domain at the C-terminus. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune response, signaling cascades and developmental processes) through the targeting of proteins, such as cyclins and cyclin-dependent kinase inhibitors (CDKNs), for degradation by the proteasome after ubiquitination. FBL18 directly interacts with SKP1A p19 and CUL-1, forming a substrate-recognition component of the SCF-type E3 ubiquitin ligase complex. Four isoforms of FBL18 exist due to alternative splicing. Function: FBXL18 is a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Database links: Entrez Gene: 80028 Human Omim: 609084 Human SwissProt: Q96ME1 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
FBL18(F-box和富含亮氨酸的重复蛋白18)又称FBXL18，是一种805个氨基酸的蛋白质，在N端附近含有一个F-box，接着是几个富含亮氨酸的重复，在C端有一个跨膜结构域。F-box蛋白是SCF(Skp1-CUL-1-F-box蛋白)型E3泛素连接酶复合物的关键成分，参与底物识别和泛素化募集。它们是通过靶向蛋白质，如细胞周期素和周期素依赖性激酶inhi，参与调节多种细胞过程（包括细胞周期、免疫应答、信号级联和发育过程）的大蛋白家族的成员。噬菌体（CDKNs），在泛素化后由蛋白酶体降解。FBL18与SKP1A p19和CUL-1直接相互作用，形成SCF型E3泛素连接酶复合物的基底识别成分。FBL18的四种异构体由于选择性剪接而存在。