FITC标记的抑制素A/Inhibin α抗体
产品名称： FITC标记的抑制素A/Inhibin α抗体
英文名称： Anti-Inhibin Alpha/FITC
产品编号： HZ-7130R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-Inhibin Alpha/FITC Conjugated antibody
FITC标记的抑制素A/Inhibin α抗体
| 英文名称 | Anti-Inhibin Alpha/FITC |
| 中文名称 | FITC标记的抑制素A/Inhibin α抗体 |
| 别 名 | A inhibin subunit precursor; IHA; INHA; Inhibin alpha chain; Inhibin alpha chain precursor; Inhibin alpha subunit; INHA_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 神经生物学 信号转导 生长因子和激素 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, Monkey, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 15kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Inhibin Alpha |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Function: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Subunit: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Subcellular Location: Secreted. Tissue Specificity: Originally found in ovary (granulosa cells) and testis (Sertoli cells), but widely distributed in many tissues including brain and placenta. In adrenal cortex expression is limited to the zona reticularis and the innermost zona fasciculate in the normal gland, extending centripetally into the zona fasciculata in hyperplasia. Also found in adrenocortical tumors. Also expressed in prostate epithelium of benign prostatic hyperplasia, in regions of basal cell hyperplasia and in nonmalignant regions of high grade prostate cancer. Only circulating inhibin B is found in male, whereas circulating inhibins A and B are found in female. Post-translational modifications: Proteolytic processing yields a number of bioactive forms. The 20/23 kDa forms consist solely of the mature alpha chain, the 26/29 kDa forms consist of the most N-terminal propeptide linked through a disulfide bond to the mature alpha chain, the 50/53 kDa forms encompass the entire proprotein. Each type can be furthermore either mono- or diglycosylated, causing the mass difference. Similarity: Belongs to the TGF-beta family. Database links: Entrez Gene: 3623 Human Entrez Gene: 16322 Mouse Entrez Gene: 24504 Rat Omim: 147380 Human SwissProt: P05111 Human SwissProt: Q04997 Mouse SwissProt: P17490 Rat Unigene: 407506 Human Unigene: 1100 Mouse Unigene: 8831 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Inhibin-α是一种二聚体蛋白质激素，由卵巢粒层细胞产生，能抑制垂体促性腺激素的产生和分泌。该抗体用于研究生殖轴基质性肿瘤 |
抑制素α亚基连接βA或βB亚基以形成垂体FSH分泌抑制剂。Inhibin已被证明负调节性腺基质细胞增殖，并具有肿瘤抑制活性。此外，血清抑制素水平已显示反映颗粒细胞肿瘤的大小，因此可用作原发性和复发性疾病的标志。然而，在前列腺癌中，抑制素α亚单位基因的表达被抑制，并且在低分化的肿瘤细胞中未检测到。此外，由于在性腺和各种性腺外组织中的表达可以以组织特异性的方式变化几倍，因此提出抑制素可以是生长/分化因子和激素。