FITC标记的尿路上皮特异蛋白1a抗体
产品名称： FITC标记的尿路上皮特异蛋白1a抗体
英文名称： Anti-Uroplakin Ia/FITC
产品编号： HZ-13704R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
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Rabbit Anti-Uroplakin Ia/FITC Conjugated antibody
FITC标记的尿路上皮特异蛋白1a抗体
| 英文名称 | Anti-Uroplakin Ia/FITC |
| 中文名称 | FITC标记的尿路上皮特异蛋白1a抗体 |
| 别 名 | UPK1A_HUMAN; Uroplakin-1a; UP1a; Tetraspanin-21; Tspan-21; Uroplakin Ia; UPIa; UPKa. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 信号转导 跨膜蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 29kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Uroplakin Ia |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The asymmetric unit membrane (AUM) forms numerous plaques, which cover the apical surface of the urothelium. These plaques are thought to strengthen the urothelium and reduce the risk of rupturing during ladder distention. They are composed of four major integral membrane proteins called uroplakins (UP). The uroplakin family comprises UPIa, UPIb, UPII, and UPIII. Family members are conserved among several species, including human, mouse, rat, rabbit, dog, pig and sheep. UPIa and UPIb form tightly packed structures with UPII and UPIII, respectively. This pairing is required for normal urothelial plaque formation and is regulated by proteolytic processing of the uroplakin proteins. Uroplakins are expressed in normal urothelium and are used as specific markers of urothelial differentiation. They are also expressed in a majority of transitional cell carcinomas of the bladder (TCCs), which make the uroplakins a useful marker for detecting bladder cancer metastasis and for staging and monitoring chemotherapeutic response. Function: Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. Subunit: Homodimer; disulfide-linked. Interacts with uroplakin-2 (UPK2). Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: High expression restricted to ureteric urothelium (most superficial cells); low expression in prostate. Expression in normal urothelial cells is lost in culture. Some expression in tumor cell lines derived from urothelial malignancies. Similarity: Belongs to the tetraspanin (TM4SF) family. Database links: Entrez Gene: 11045 Human Omim: 611557 Human SwissProt: O00322 Human SwissProt: Q3KNU5 Human SwissProt: Q3KNU6 Human Unigene: 159309 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
非对称单位膜（AUM）形成许多斑块，覆盖尿道上皮的顶端表面。这些斑块被认为能增强尿路上皮并减少在扩张过程中破裂的风险。它们由四个主要的整合膜蛋白称为尿斑蛋白（UP）。uroplakin家族包括UPIA、UPIB、UPII和UPIII。家庭成员在人类、老鼠、大鼠、兔子、狗、猪和羊等物种中是保守的。UPIA和UPIB分别与UPII和UPIII形成紧密堆积的结构。这种配对是正常尿路上皮斑块形成所必需的，并且由尿路上皮蛋白的蛋白水解过程调节。尿路蛋白在正常尿路上皮中表达，并作为尿路上皮分化的特异性标志物。在大多数膀胱移行细胞癌（TCC）中也有表达，这使尿激酶成为检测膀胱癌转移和分期及moni的有用标志物。