FITC标记的转录延伸因子结合蛋白1抗体
产品名称： FITC标记的转录延伸因子结合蛋白1抗体
英文名称： Anti-REXO1/FITC
产品编号： HZ-19839R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-REXO1/FITC Conjugated antibody
FITC标记的转录延伸因子结合蛋白1抗体
| 英文名称 | Anti-REXO1/FITC |
| 中文名称 | FITC标记的转录延伸因子结合蛋白1抗体 |
| 别 名 | EloA BP1; ELOABP1; Elongin A binding protein 1; KIAA1138; REX1, RNA exonuclease 1 homolog (S. cerevisiae); RNA exonuclease 1 homolog; TCEB3BP1; Transcription elongation factor B polypeptide 3 binding protein 1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 131kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human REXO1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: REXO1 or Elongin A-binding protein 1 (EloA-BP1) is an exonuclease domain-containing protein that can bind to Elongin. The Elongin complex stimulates the rate of transcription elongation by RNA polymerase II by suppressing the transient pausing of the polymerase at many sites along the DNA template. REXO1 is composed of 1221 amino acids and its mRNA is ubiquitously expressed. EloA-BP1 is capable of binding not only the NH(2)-terminal approximately 120 amino acid region of Elongin A, but also that of SII. Although REXO1 had no detectable effect on the rate of transcription elongation in vitro, it may play some role in the regulation of elongation in vivo. Function: Seems to have no detectable effect on transcription elongation in vitro. Subunit: Interacts with TCEA2 and TCEB3. Subcellular Location: Nuclear Similarity: Belongs to the REXO1/REXO3 family. Contains 1 exonuclease domain. Database links: Entrez Gene: 57455 Human Omim: 609614 Human SwissProt: Q8N1G1 Human Unigene: 192477 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
RXO1或细长素A结合蛋白1（EOLA-BP1）是与Elongin结合的核酸外切酶结构域蛋白。Elongin复合物通过抑制聚合酶沿DNA模板在许多位点的短暂停顿来刺激RNA聚合酶II的转录延长速率。RXO1由1221个氨基酸组成，其mRNA普遍表达。EloA-BP1不仅可以结合Elongin A的大约120个氨基酸区的NH(2)-末端，而且可以结合SII。尽管REXO1在体外对转录伸长率没有明显影响，但它可能在调节细胞周期和转录周期方面起一定作用。