FITC标记的CMBL蛋白抗体
产品名称： FITC标记的CMBL蛋白抗体
英文名称： Anti-CMBL/FITC
产品编号： HZ-
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-CMBL/FITC Conjugated antibody
FITC标记的CMBL蛋白抗体
| 英文名称 | Anti-CMBL/FITC |
| 中文名称 | FITC标记的CMBL蛋白抗体 |
| 别 名 | LOC134147; Carboxymethylenebutenolidase homolog (Pseudomonas); Carboxymethylenebutenolidase homolog; cmbl; CMBL_HUMAN; FLJ23617. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 28kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CMBL |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: CMBL is a 245 amino acid cytosolic protein and cysteine hydrolase that preferentially cleaves cyclic esters. A member of the dienelactone hydrolase family, CMBL is the human homolog of Pseudomonas dienelactone hydrolase, a protein that participates in the bacterial halocatechol degradation pathway. CMBL is ubiquitously expressed with high expression in liver, colon, kidney and small intestine, where it acts as a bioactivating enzyme for a prodrug type angiotensin II type 1 receptor antagonist known as olmesartan medoxomil. CMBL is inhibited by p-chloromercuribenzoate (PCMB) and is encoded by a gene that maps to human chromosome 5p15.2. Chromosome 5 contains 181 million base pairs and comprises nearly 6% of the human genome. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm, or of chromosome 5 altogether, is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome. Function: Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin. Subcellular Location: Cytoplasm > cytosol. Tissue Specificity: Widely expressed, with highest levels in liver, followed by kidney, small intestine and colon. Present in liver and intestine (at protein level). Similarity: Belongs to the dienelactone hydrolase family. Database links: Entrez Gene: 134147 Human SwissProt: Q96DG6 Human Unigene: 192586 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
CMBL是一种245个氨基酸的胞浆蛋白和半胱氨酸水解酶，优先裂解环状酯。CMBL是二烯内酯水解酶家族的成员，是假单胞菌二烯内酯水解酶的人类同源物，该酶是参与细菌卤代乙酰胆碱降解途径的蛋白质。CMBL在肝脏、结肠、肾脏和小肠中高表达，作为前药型血管紧张素II 1型受体拮抗剂奥美沙坦美多酚的生物活性酶。对氯*甲酸酯（PCMB）抑制CMBL，并由一个映射到人类染色体5p152的基因编码。第5染色体包含1亿8100万个碱基对，并包含人类基因组的近6%。5号染色体p臂缺失导致Cri du chat综合征，而q臂缺失或5号染色体缺失在治疗相关的急性髓细胞白血病和骨髓增生异常综合征中很常见。