FITC标记的卵黄状黄斑病蛋白3抗体
产品名称： FITC标记的卵黄状黄斑病蛋白3抗体
英文名称： Anti-Bestrophin 3/FITC
产品编号： HZ-11042R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Bestrophin 3/FITC Conjugated antibody
FITC标记的卵黄状黄斑病蛋白3抗体
| 产品编号 | bs-11042R-FITC |
| 英文名称 | Anti-Bestrophin 3/FITC |
| 中文名称 | FITC标记的卵黄状黄斑病蛋白3抗体 |
| 别 名 | Vitelliform macular dystrophy 2 like protein 3; BEST 3; BEST3; BEST3_HUMAN; Bestrophin-3; Bestrophin3; Vitelliform macular dystrophy 2 like 3; Vitelliform macular dystrophy 2-like protein 3; VMD2L3. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 信号转导 通道蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Horse, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 76kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Bestrophin 3 (45-92aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Bestrophin-3 is a 668 amino acid member of the Bestrophin family of proteins. Members of the Bestrophin family are transmembrane proteins that contain a high percentage of aromatic residues, a conserved RFP (arg-phe-pro) motif and they function as anion channels. Expressed predominantly in skeletal muscle but also found in spinal cord, brain, testis, thymus, retina and bone marrow, Bestrophin-3 forms calcium-sensitive chloride channels. In addition, Bestrophin-3 contains an AI (auto-inhibitory) domain that is capable of regulating the anion channel activity. Due to alternative splicing events, three isoforms exist for Bestrophin-3. Function: Forms calcium-sensitive chloride channels. Permeable to bicarbonate. Subcellular Location: Cell membrane. Tissue Specificity: Present in skeletal muscle and weakly in brain, spinal cord, bone marrow and retina. Similarity: Belongs to the bestrophin family. Database links: UniProtKB/Swiss-Prot: Q8N1M1.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Bestopin -3是Bestrophin蛋白家族的668氨基酸成员。Bestrophin家族的成员是含有高比例的芳香族残基的跨膜蛋白，保守的RFP（ARG-PHE-PRO）基序，它们作为阴离子通道发挥作用。主要在骨骼肌中表达，但也存在于脊髓、脑、睾丸、胸腺、视网膜和骨髓中，Bestopin -3形成钙敏感的氯离子通道。此外，Bestopin -3包含AI（自动抑制）域，其能够调节阴离子通道活性。由于选择性剪接事件，三种异构体存在于Bestopin -3。