FITC标记的GTP结合蛋白7抗体
产品名称： FITC标记的GTP结合蛋白7抗体
英文名称： Anti-MTG1/GTPBP7/FITC
产品编号： HZ-17874R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-MTG1/GTPBP7/FITC Conjugated antibody
FITC标记的GTP结合蛋白7抗体
| 英文名称 | Anti-MTG1/GTPBP7/FITC |
| 中文名称 | FITC标记的GTP结合蛋白7抗体 |
| 别 名 | GTP; GTP binding protein; GTP binding protein 7 (putative); GTP binding protein 7; GTP-binding protein 7 (putative); GTP-binding protein 7; GTPBP7; Mitochondrial GTPase 1; mitochondrial GTPase 1 homolog (S. cerevisiae); MTG1; MTG1_HUMAN; OTTHUMP00000020814; OTTHUMP00000046565; RP11 108K14.2; RP11-108K14.2; RP11108K14.2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 转录调节因子 转运蛋白 线粒体 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Cow, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 37kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MTG1/GTPBP7 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: MTH1 is a 179 amino acid cytoplasmic protein that is a member of the nudix hydrolase family. Highly expressed in testis, thymus and proliferating blood lymphocytes, MTH1 functions as an antimutagenic that hydrolyzes oxidized purine nucleoside triphosphates to their corresponding monophosphates. Through its ability to enzymatically hydrolyze ATP and GTP to AMP and GMP, respectively, MTH1 prevents misincorporation of GTP into DNA, thus preventing A:T to C:G transversions. The cytoplasmic location of MTH1, along with its antimutagenic capabilities, suggests that it may also be involved in the sanitization of nucleotide pools for both mitochondrial and nuclear genomes. Four isoforms of MTH1 exist—three of which are formed due to alternative splicing events and one of which is formed via a single-nucleotide polymorphism. Overexpression of MTH1 is implicated in prostate and cell lung carcinomas Function: Mitochondrial GTPase. May be involved in assembly of the large ribosomal subunit. Subcellular Location: Mitochondrion. Similarity: Belongs to the MMR1/HSR1 GTP-binding protein family. MTG1 subfamily. Contains 1 G (guanine nucleotide-binding) domain. Database links: Entrez Gene: 92170 Human Entrez Gene: 509768 Cow Entrez Gene: 212508 Mouse SwissProt: Q4PS77 Cow SwissProt: Q9BT17 Human SwissProt: Q8R2R6 Mouse Unigene: 501578 Human Unigene: 296088 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
MTH1是Nudix水解酶家族成员中的179氨基酸胞质蛋白。MTH1在睾丸、胸腺和增殖的血淋巴细胞中高度表达，具有将氧化的嘌呤核苷三磷酸水解成相应的单磷酸盐的抗突变作用。MTH1通过将ATP和GTP分别酶解为AMP和GMP的能力，防止了GTP与DNA的错配，从而防止了A:T到C:G的转换。MTH1的细胞质位置及其抗突变能力表明它也可能参与线粒体和核基因组的核苷酸池的消毒。存在四种MTH1亚型，其中三种是由于选择性剪接事件形成的，一种是通过单核苷酸多态性形成的。MTH1的过度表达与前列腺癌和细胞肺癌有关