FITC标记的原钙粘附蛋白β1抗体
产品名称： FITC标记的原钙粘附蛋白β1抗体
英文名称： Anti-PCDHB1/FITC
产品编号： HZ-13724R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-PCDHB1/FITC Conjugated antibody
FITC标记的原钙粘附蛋白β1抗体
| 英文名称 | Anti-PCDHB1/FITC |
| 中文名称 | FITC标记的原钙粘附蛋白β1抗体 |
| 别 名 | MGC138301; MGC138303; PCDB1_HUMAN; PCDH beta1; PCDH-beta-1; PCDHB 1; PCDHB1; Protocadherin beta 1; Protocadherin beta-1; |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 细胞粘附分子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 90kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PCDHB1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain. There are three protocadherin gene clusters, designated alpha, beta and gamma, all of which contain multiple tandemly arranged genes. PCDHB1 (Protocadherin beta 1) is an 818 amino acid protein that is one of 16 proteins in the protocadherin beta cluster. Unlike the alpha and gamma gene clusters whose genes are spliced to downstream constant region exons during transcription, members of the beta cluster (such as PCDHB1) do not use constant-region exons to produce mRNAs. As a result, each protocadherin beta gene encodes the transmembrane, extracellular and short cytoplasmic domains of the protein. PCDHB1 is a single-pass type I membrane protein containing six cadherin domains. Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Subcellular Location: Cell membrane. Similarity: Contains 6 cadherin domains. Database links: Entrez Gene: 29930 Human Omim: 606327 Human SwissProt: Q9Y5F3 Human Unigene: 278950 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
原钙粘附素是钙粘附素样细胞粘附蛋白的一个大家族，参与建立和维持大脑中的神经元连接。原钙粘蛋白基因簇有三个，分别命名为α、β和γ，它们都包含多个串联排列的基因。PCDHB1（原粘蛋白β1）是818种氨基酸蛋白，是原粘蛋白β簇中的16种蛋白质之一。与α和γ基因簇不同，它们的基因在转录过程中被拼接到下游恒定区外显子，β基因簇的成员（如PCDHB1）不使用恒定区外显子来产生mRNA。结果，每个原粘蛋白β基因编码蛋白质的跨膜、胞外和短胞质结构域。PCDHB1是一个单通道I型膜蛋白，含有六个钙粘蛋白结构域。