FITC标记的神经源性神经营养因子抗体
产品名称： FITC标记的神经源性神经营养因子抗体
英文名称： Anti-NENF/FITC
产品编号： HZ-11502R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-NENF/FITC Conjugated antibody
FITC标记的神经源性神经营养因子抗体
| 产品编号 | bs-11502R-FITC |
| 英文名称 | Anti-NENF/FITC |
| 中文名称 | FITC标记的神经源性神经营养因子抗体 |
| 别 名 | Neudesin; Cell growth inhibiting protein 47; Cell immortalization-related protein 2; CIR2; Nenf; NENF_HUMAN; Neuron derived neurotrophic factor; Neuron-derived neurotrophic factor; SCIRP10; SCIRP10 related protein; Secreted protein of unknown function; Spinal cord injury related protein 10; SPUF; SPUF protein. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 生长因子和激素 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 16kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Neudesin |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Neudesin is a 172 amino acid secreted protein that belongs to the cytochrome b5 family and MAPR subfamily. Neudesin possesses neurotrophic activity, which is enhanced by binding to heme, and may contribute to neuronal differentiation and neural cell proliferation. In primary cultured neurons, Neudesin has been observed to activate Akt1 and ERK 1 phosphorylation. Upregulated in immortal cells, Neudesin contains one cytochrome b5 heme-binding domain and is encoded by a gene that maps to human chromosome 1q32.3. Human chromosome 1 spans 260 million base pairs and comprises nearly 8% of the human genome. A large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome, map to chromosome 1. Function: Displays neurotrophic activity and activates phosphorylation of MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT in primary cultured neurons. Does not have mitogenic activity in primary cultured astrocytes. May play a role on neuronal differentiation and may have a transient effect on neural cell proliferation in neural precursor cells. Neurotrophic activity is enhanced by binding to heme. Subcellular Location: Secreted > extracellular space. Similarity: Belongs to the cytochrome b5 family. MAPR subfamily. Contains 1 cytochrome b5 heme-binding domain. Database links: Entrez Gene: 29937 Human Entrez Gene: 66208 Mouse Entrez Gene: 289380 Rat Omim: 611874 Human SwissProt: Q9UMX5 Human SwissProt: Q9CQ45 Mouse SwissProt: Q6IUR5 Rat Unigene: 461787 Human Unigene: 46444 Mouse Unigene: 3355 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
NudEsin是一种172氨基酸分泌蛋白，属于细胞色素b5家族和MAPR亚家族。NudEsin具有神经营养活性，通过与血红素结合而增强，并可能有助于神经元分化和神经细胞增殖。在原代培养的神经元中，已观察到NudEsIN激活Akt1和ERK1磷酸化。在不朽细胞中上调，NudEsIn包含一个细胞色素b5血红素结合域，并由一个映射到人类染色体1q32.3的基因编码。人类一号染色体上有2.6亿个碱基对，占人类基因组的近8%.大量的疾病相关基因，包括家族性腺瘤性息肉病、Stutkle综合征、帕金森氏病、高雪氏病、精神分裂症和阿瑟小子综合征，映射到第1号染色体上。