人食道上皮细胞
产品名称： 人食道上皮细胞
英文名称： Human Esophageal Microvascular Epithelial Cells
产品编号： 2700
产品价格： 0
产品产地： 进口
品牌商标： 美国
更新时间： 2024-10-31T09:25:54
使用范围： null
- 联系人 : 胡小姐
- 地址 : 上海市宝山区长江南路180号A区401-406室
- 邮编 : 200433
- 所在区域 : 上海
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上海复蒙基因生物科技有限公司是美国Sciencell公司官网公布的一级代理商： 美国ScienCell研究实验室（www.sciencellonline.com）成立于1999年，公司总部位于美国加州的圣地亚哥。主要致力于实验室科研用原代细胞、原代细胞专用培养基、原代细胞无血清培养基、干细胞、干细胞培养基、干细胞无血清培养基的研究和开发，在全球拥有众多客户。在国内销售8年来，很多老师应用其产品发表了高质量的SCI文章，且有着极高的文献引用率。凭借着严格的质控和优秀的产品品质，深受广大科研工作者的信赖。 请登录Sciencell公司官方网站（www.sciencell-sh.com或www.sciencellonline.com）以确保购买正规公司产品。
产品： 人食道上皮细胞
货号：2700
Description Endothelial cells lining the microvasculature are known to play a critical “gatekeeper” role in the inflammatory process through their ability to recruit circulating immune cells into tissues and foci of inflammation. Studies show that esophageal microvascular endothelial cells exhibit a strong inflammatory immune response to LPS, cytokines, and pH exposure, thus playing a critical regulatory role in esophageal inflammation [1]. When exposed to acidic pH, HEMEC express some proteins, such as VCAM-1, but not others, such as ICAM-1, which is speculated to selectively recruit leukocytes to the esophagus [2]. This could play a role in the cellular response triggered by gastroesophageal reflux disease. In vitro cultures of HEMEC have enabled scientists to observe leukocyte binding, upregulation of cell adhesion molecules, and other cellular responses to LPS, cytokines and pH exposure that indicate that HEMECs are intrinsically different from lower gastrointestinal endothelial cells in regards to an inflammatory immune response [3]. HEMEC from ScienCell Research Laboratories are isolated from human esophageal tissue. HEMEC are cryopreserved at passage one and delivered frozen. Each vial contains >5 x 105 cells in 1 ml volume. HEMEC are characterized by immunofluorescent method with antibodies to vWF/Factor VIII and CD31 (P-CAM) and by uptake of DiI-Ac-LDL. HEMEC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HEMEC are guaranteed to further culture in the conditions provided by ScienCell Research Laboratories.
It is recommended to use Endothelial Cell Medium (ECM, Cat. No. 1001) for the culturing of HEMEC in vitro.
HEMEC are for research use only. It is not approved for human or animal use, or for application in in vitro diagnostic procedures.
Directly and immediately transfer cells from dry ice to liquid nitrogen upon receiving and keep the cells in liquid nitrogen until cell culture needed for experiments.
Dry ice.
[1], [3]. Rafiee, P., Ogawa, H., Heidemeann, J., Li, MS., Aslam, M., Lamirand, TH., Risher, PJ., Graewin, SJ., Dwinell, MB., Johnson, CP., Shaker, R., Binion, DG. (2003) Isolation and characterization of human esophageal microvascular endothelial cells: mechanisms of inflammatory activation. Am J Physiol Gastroinest Liver Physiol. 285(6): G1277-92. 如需要其他产品资料请发邮件至wwwfudan@163.com索取 Sciencell公司其它产品： 原代细胞（纯度可达98％。其中包括21种人体正常细胞系统，90多种不同细胞类型。大多数细胞在全球唯有ScienCell实验室能够成功分离。） 复蒙基因|FMGBio(www.fmgbio.com/ www.sciencell-sh.com/ )成立于2005年， 是专业从事牛血清生产、销售高端的原代细胞类科研产品。这些产品从根本上提高了全球生命医学研究、人类重要疾病药物研发、新药研发的成功率。近几年的新药研发成功率在逐年下降，其根本原因之一就是传统的药物筛选系统是建立在只具有30-40%人类基因群的一系列细胞株上。这样一个有“缺陷型”药物筛选系统所产生的药物用于人体上就会出现许多致命的弱点和不完整性。新一代药物筛选系统是含有一系列近乎完整的人类基因群的原代细胞株。而利用这些原代细胞株所甄别和筛选出来的候选药物，其诊治人类疾病的成功几率将大大增加。这样不但大大节省了新药的开发成本，而且将极大地提高人类的健康质量。 复蒙基因|FMGBio现有的产品：美国Sciencell（原代细胞、原代细胞专用培养基、无血清培养基）、3D Bioteck（三维细胞培养支架）、年产1000万毫升的内蒙古牛血清生产基地等。
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