FITC标记的RNA结合蛋白10抗体
产品名称： FITC标记的RNA结合蛋白10抗体
英文名称： Anti-RBM10/FITC
产品编号： HZ-19762R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-RBM10/FITC Conjugated antibody
FITC标记的RNA结合蛋白10抗体
| 英文名称 | Anti-RBM10/FITC |
| 中文名称 | FITC标记的RNA结合蛋白10抗体 |
| 别 名 | DXS8237E; G patch domain containing protein 9; G patch domain-containing protein 9; GPATC9; GPATCH9; HGNC9896; KIAA0122; MGC1132; MGC997; Rbm10; RBM10_HUMAN; RNA binding motif protein 10; RNA binding protein 10; RNA binding protein S1-1; RNA-binding motif protein 10; RNA-binding protein 10; RNA-binding protein S1-1; S1-1; TARPS; ZRANB5. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 结合蛋白 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 103kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RBM10 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a nuclear protein that belongs to a family proteins that contain an RNA-binding motif. The encoded protein associates with hnRNP proteins and may be involved in regulating alternative splicing. Defects in this gene are the cause of the X-linked recessive disorder, TARP syndrome. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2011] Function: May be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A). Subunit: Associates with the spliceosome. Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF,RBM10 and KIF11/TRIP5. Subcellular Location: Nucleus. In the extranucleolar nucleoplasm constitutes hundreds of nuclear domains, which dynamically change their structures in a reversible manner. Upon globally reducing RNA polymerase II transcription, the nuclear bodies enlarge and decrease in number. They occur closely adjacent to nuclear speckles or IGCs (interchromatin granule clusters) but coincide with TIDRs. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. DISEASE: Defects in RBM10 are the cause of TARP syndrome (TARPS) [MIM:311900]. It is a disorder characterized by the Robin sequence (micrognathia, glossoptosis and cleft palate), talipes equinovarus and cardiac defects. Similarity: Contains 1 C2H2-type zinc finger. Contains 1 G-patch domain. Contains 1 RanBP2-type zinc finger. Contains 2 RRM (RNA recognition motif) domains. Database links: Entrez Gene: 8241 Human Entrez Gene: 236732 Mouse Omim: 300080 Human SwissProt: P98175 Human SwissProt: Q99KG3 Mouse Unigene: 401509 Human Unigene: 279194 Mouse Unigene: 383632 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
该基因编码属于包含RNA结合基序的家族蛋白的核蛋白。编码的蛋白与HNRNP蛋白相关，并可能参与调节选择性剪接。该基因的缺陷是X连锁隐性遗传性TARP综合征的原因。交替剪接导致多个转录变体。（RefSeq，MAR 2011提供）