FITC标记的RAS相关GTP结合蛋白B抗体
产品名称： FITC标记的RAS相关GTP结合蛋白B抗体
英文名称： Anti-RRAGB/FITC
产品编号： HZ-10987R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-RRAGB/FITC Conjugated antibody
FITC标记的RAS相关GTP结合蛋白B抗体
| 英文名称 | Anti-RRAGB/FITC |
| 中文名称 | FITC标记的RAS相关GTP结合蛋白B抗体 |
| 别 名 | GTP-binding protein ragB; Rag B; RagB; Ras-related GTP-binding protein B; RRAGB; RRAGB_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 染色质和核信号 信号转导 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 43kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RRAGB |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008] Function: Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. Subunit: Interacts with RRAGC and RRAGD; heterodimerization stabilizes RRAG proteins. In complex with RRAGC, but not with RRAGA, interacts with RPTOR; this interaction is particularly efficient with GTP-loaded RRAGB and GDP-loaded RRAGC. Interacts with SH3BP4; the interaction with this negative regulator is most probably direct, preferentially occurs with the inactive GDP-bound form of RRAGB, is negatively regulated by amino acids and prevents interaction with RPTOR. Subcellular Location: Cytoplasm. Lysosome. Similarity: Belongs to the GTR/RAG GTP-binding protein family. Database links: Entrez Gene: 506754 Cow Entrez Gene: 10325 Human Entrez Gene: 491907 Dog Entrez Gene: 100724885 Guinea pig Entrez Gene: 100629499 Horse Entrez Gene: 245670 Mouse Entrez Gene: 100346402 Rabbit Entrez Gene: 100909655 Rat Entrez Gene: 117043 Rat Entrez Gene: 101107847 Sheep Entrez Gene: 325358 Zebrafish Omim: 300725 Human SwissProt: Q5VZM2 Human SwissProt: Q6NTA4 Mouse SwissProt: Q63487 Rat Unigene: 50282 Human Unigene: 190922 Mouse Unigene: 203382 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Ras同源GTPases构成了一个信号转导家族，在激活的GTP结合状态和非激活的GDP结合状态之间交替。这些蛋白代表由GTP交换因子和刺激其内在GTP酶活性的因素操作的细胞开关。Ras超家族的所有GTP酶共有六个参与GTP/GDP结合的保守基序，其中三个是磷酸盐/镁结合位点(PM1-PM3)，三个是鸟嘌呤核苷酸结合位点(G1-G3)。已经鉴定出编码不同亚型的转录变体。[ RefSeq，JUL 2008 ]