TSKS,睾丸特异激酶底物蛋白抗体

产品编号HZ-11413R
英文名称TSKS
中文名称睾丸特异激酶底物蛋白抗体
别 名STK22 substrate 1; Stk22s1; Testis specific kinase substrate; Testis specific serine kinase substrate; TSKS; TSKS1; MGC134104; TSKS_HUMAN.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 发育生物学 神经生物学 信号转导 干细胞
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep,
TSKS,睾丸特异激酶底物蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量65kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human TSKS (121-170aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
TSKS,睾丸特异激酶底物蛋白抗体PubMedPubMed
产品介绍background:
TSKS is a 592 amino acid protein that is highly expressed in human testicular tissue. Low levels of TSKS are detectable in prostate, placenta, fetal liver, thymus, and mammary gland tissues. TSKS is found to be downregulated in cancerous testicular tissue from seminoma, teratocarcinoma, embryonal and Leydig cell tumors concurrently with high expression in neighboring premalignant carcinoma. TSKS protein contains an N-terminal signal peptide, but does not contain a transmembrane region. TSKS has many potential phosphorylation and glycosylation sites and is phosphorylated by soluble recombinant TSSK2 in vitro. It is thought that TSKS likely plays a physiological role in spermatogenesis or spermiogenesis.

Function:
A novel putative serine/threonine kinase substrate gene (TSKS, for testis-specific kinase substrate) is likely the human homolog of the mouse testis-specific serine kinase substrate gene. TSKS exhibits high levels of expression exclusively in human testicular tissue. The expression of TSKS is downregulated in cancerous testicular tissue, in comparison to adjacent normal tissue. These observations suggest a role of TSKS in testicular physiology, most probably in the process of spermatogenesis or spermiogenesis.

Subcellular Location:
Cytoplasmic

Tissue Specificity:
Highly expressed in testis. Expressed at low levels in prostate, female breast, placenta, ovary and thymus.

Post-translational modifications:
Phosphorylated on serine residue(s) by STK22A/TSSK1 and STK22B/TSSK2.

Database links:
UniProtKB/Swiss-Prot: Q9UJT2.3

TSKS,睾丸特异激酶底物蛋白抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.