FITC标记的钠钾离子转运蛋白1抗体
产品名称： FITC标记的钠钾离子转运蛋白1抗体
英文名称： Anti-NKCC1/SLC12A2/FITC
产品编号： HZ-6945R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200
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Rabbit Anti-NKCC1/SLC12A2/FITC Conjugated antibod
FITC标记的钠钾离子转运蛋白1抗体
| 产品编号 | bs-6945R-FITC |
| 英文名称 | Anti-NKCC1/SLC12A2/FITC |
| 中文名称 | FITC标记的钠钾离子转运蛋白1抗体 |
| 别 名 | Basolateral Na-K-Cl symporter; BSC; BSC2; Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1; mBSC2; NKCC1; S12A2_HUMAN; SLC12A2; sodium-potassium-chloride cotransporter 1; solute carrier family 12 (sodium/potassium/chloride transporters) member 2; Solute carrier family 12 member 2; sy-ns. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 心血管 细胞生物 神经生物学 信号转导 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Chimpanzee, |
| 产品应用 | Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 132kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NKCC1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Na-K-Cl cotransporters (NKCC) are channel proteins that aid in the transcellular movement of chloride across both secretory and absorptive epithelia. NKCC1 is expressed in muscle cells, neurons, and red blood cells. In the basolateral membrane of secretory epithelia, NKCC1 mediates active chloride secretion. The gene encoding human NKCC1 maps to chromosome 5q23.3. In mice, disruption of the NKCC1 gene leads to deafness and impaired balance. NKCC2 is specifically expressed in the kidney where it mediates active reabsorption of sodium chloride in the thick ascending limb of the loop of Henle. NKCC2 is sensitive to the clinically important diuretics furosemide and bumetanide. The gene encoding human NKCC2 maps to chromosome 15q15-q21 and mutations in this gene lead to Bartter’s syndrome, an inherited hypokalaemic alkalosis. NCCT is a thiazide-sensitive Na-Cl cotransporter that is primarily expressed in the distal convoluted tubule of the kidney where it accounts for a significant fraction of net renal sodium reabsorption. The gene for human NCCT map to chromosome 16q13. Mutations in the gene encoding NCCT cause Gitelman’s syndrome, a subset of Bartter’s syndrome. Function: Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Expressed in many tissues. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the SLC12A transporter family. Database links: Entrez Gene: 471620 Chimpanzee Entrez Gene: 286845 Cow Entrez Gene: 481490 Dog Entrez Gene: 6558 Human Entrez Gene: 20496 Mouse Entrez Gene: 100516960 Pig Entrez Gene: 83629 Rat Omim: 600840 Human SwissProt: P55011 Human SwissProt: P55012 Mouse Unigene: 162585 Human Unigene: 712970 Human Unigene: 399997 Mouse Unigene: 11523 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Na-K-CL共转运蛋白（NKCC）是通道蛋白，有助于氯离子跨分泌和吸收上皮细胞的跨细胞运动。NKC1在肌肉细胞、神经元和红细胞中表达。在分泌上皮的基底膜中，NKC1介导活性氯化物分泌。编码人类NKC1基因的基因编码到染色体5q23.3。在小鼠中，NKC1基因的破坏导致耳聋和平衡失调。NKCc2在肾脏中特异性表达，在Henle环的粗大上升肢体中介导氯化钠的主动再吸收。NKC2对临床上重要的利尿剂呋塞米和布美他尼敏感。编码人类NKCK2的基因被编码到染色体15q15q21，该基因的突变导致Bartter综合征，遗传性低钾血症性碱中毒。NCCT是一种噻嗪敏感的Na Cl cotransporter，主要在肾脏的远端曲小管中表达，其中它占净肾钠重吸收的一个重要部分。人类NCCT基因到16q13染色体。NCCT基因突变导致GITelman综合征，Bartter综合征的一个子集。