FITC标记的C型凝集素受体CLEC13A抗体
产品名称： FITC标记的C型凝集素受体CLEC13A抗体
英文名称： Anti-DCL-1/FITC
产品编号： HZ-13760R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-DCL-1/FITC Conjugated antibody
FITC标记的C型凝集素受体CLEC13A抗体
| 英文名称 | Anti-DCL-1/FITC |
| 中文名称 | FITC标记的C型凝集素受体CLEC13A抗体 |
| 别 名 | CD302; CLEC13A; DCL1; C-type lectin domain family 13 member A; C-type lectin BIMLEC; CD302_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 细胞粘附分子 细胞表面分子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Horse, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 26kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DCL-1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈. |
| 产品介绍 | background: DCL-1 is a 232 amino acid single-pass type I membrane protein involved in endocytosis, phagocytosis and cell adhesion and migration. A C-type lectin receptor, DCL-1 is widely expressed with highest levels found in peripheral blood, myeloid and B lymphoid cell lines, liver, ovary and lung. DCL-1 undergoes alternative splicing to produce three isoforms designated DCL-1 isoform 1, isoform 2 (also known as fusion protein variant V34-2) and isoform 3 (also designated fusion protein variant V33-2). DCL-1 isoforms 2 and 3 are produced in malignant lympoma cells, known as Hodgkin and Reed-Sternberg (HRS) cells. DCL-1 contains one C-type lectin domain and is encoded by a gene that maps to human chromosome 2q24.2. A number of genetic diseases are linked to genes on chromosome 2 including Harlequin icthyosis, sitosterolemia and Alstr鰉 syndrome. Function: Expressed in myeloid and B lymphoid cell lines. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells. Subcellular Location: Membrane. Similarity: Contains 1 C-type lectin domain. Database links: Entrez Gene: 9936 Human Entrez Gene: 66205 Mouse Entrez Gene: 295629 Rat Omim: 612246 Human SwissProt: Q8IX05 Human SwissProt: Q9DCG2 Mouse SwissProt: Q5FVR3 Rat Unigene: 130014 Human Unigene: 674903 Human Unigene: 227281 Mouse Unigene: 98436 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
DCL-1是一个232个氨基酸的单程I型膜蛋白，参与内吞、吞噬和细胞粘附和迁移。DCL-1是一种C型凝集素受体，广泛表达于外周血、骨髓和B淋巴细胞系、肝脏、卵巢和肺中。DCL-1通过选择性剪接产生三种异构体命名为DCL-1异构体1、异构体2(也称为融合蛋白变体V34-2)和异型体3(也称为融合蛋白变体V33-2)。DCL-1异构体2和3在恶性淋巴瘤细胞中产生，称为霍奇金和Reed Sternberg（HRS）细胞。DCL-1包含一个C型凝集素结构域，并由一个映射到人类染色体2q24.2的基因编码。许多遗传疾病与第2染色体上的基因相关，包括小丑鱼鳞病、谷固醇血症和Alstr鰉综合征。