FITC标记的DNA断裂因子抗体（蛋白酶激活脱氧核糖核酸酶）
产品名称： FITC标记的DNA断裂因子抗体（蛋白酶激活脱氧核糖核酸酶）
英文名称： Anti-DFFB/FITC
产品编号： HZ-7648R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-DFFB/FITC Conjugated antibody
FITC标记的DNA断裂因子抗体（蛋白酶激活脱氧核糖核酸酶）
| 英文名称 | Anti-DFFB/FITC |
| 中文名称 | FITC标记的DNA断裂因子抗体（蛋白酶激活脱氧核糖核酸酶） |
| 别 名 | CAD; Caldesmon; Caspase activated deoxyribonuclease; Caspase activated DNase; Caspase activated nuclease; CDM; CPAN; Deoxyribonuclease III, caspase activated; DFF 40; DFF2; DFF40; Didff; DNA fragmentation factor 40 kDa subunit; DNA fragmentation factor subunit beta; DNA fragmentation factor, 40 Da, beta polypeptide (caspase activated DNase); DNA fragmentation factor, 40 kD beta subunit; DNA fragmentation factor, 40 kD, beta polypeptide; DNA fragmentation factor, 40kDa, beta polypeptide (caspase activated DNase); DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase); DNAation factor, beta subunit; DFFB_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 细胞凋亡 细胞周期蛋白 激酶和磷酸酶 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 39kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DFFB |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of these variants has not been determined. [provided by RefSeq, Jul 2008]. Function: Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology. Subunit: Heterodimer of DFFA and DFFB. Interacts with HIST1H1A. Subcellular Location: Cytoplasm. Nucleus. Similarity: Contains 1 CIDE-N domain. Database links: Entrez Gene: 1677 Human Entrez Gene: 13368 Mouse Entrez Gene: 84359 Rat Omim: 601883 Human SwissProt: O76075 Human SwissProt: O54788 Mouse SwissProt: Q99N34 Rat Unigene: 133089 Human Unigene: 388918 Mouse Unigene: 67077 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
细胞凋亡是在哺乳动物发育过程中去除有毒和/或无用细胞的细胞死亡过程。凋亡过程伴随着细胞和细胞核的收缩和碎裂，并将染色体DNA降解成核小体单位。DN**段化因子（DFF）是一个40 kD（DFFB）和45 kD（DFFA）亚基的异源二聚体蛋白。DFFA是Caspase-3的底物，在细胞凋亡过程中触发DNA断裂。当DFFA被Caspase-3裂解时，DFF被激活。DFFA的裂解片段从DFFB中分离出来，DFFB是DFF的活性成分。已发现DFFB触发细胞凋亡过程中的DNA断裂和染色质凝聚。另一种编码不同的异构体的剪接转录变体已被发现，但这些变异体的生物学有效性尚未确定。[ RefSeq，JUL 2008 ]提供。