FITC标记的VAC14蛋白抗体
产品名称： FITC标记的VAC14蛋白抗体
英文名称： Anti-VAC14/FITC
产品编号： HZ-12679R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-VAC14/FITC Conjugated antibody
FITC标记的VAC14蛋白抗体
| 英文名称 | Anti-VAC14/FITC |
| 中文名称 | FITC标记的VAC14蛋白抗体 |
| 别 名 | ArPIKfyve; FLJ10305; FLJ36622; FLJ46582; MGC149815; MGC149816; OTTHUMP00000174908; Protein VAC14 homolog; Tax1 (human T cell leukemia virus type I) binding protein 1; Tax1 (human T cell leukemia virus type I) binding protein 2; Tax1 binding protein 2; Tax1-binding protein 2; TAX1BP2; TRX; VAC 14; vac14; Vac14 homolog (S. cerevisiae); Vac14 homolog; VAC14_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 信号转导 淋巴细胞 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 88kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human VAC14 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The content of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) in endosomal membranes changes dynamically with fission and fusion events that generate or absorb intracellular transport vesicles. VAC14 is a component of a trimolecular complex that tightly regulates the level of PtdIns(3,5)P2. Other components of this complex are the PtdIns(3,5)P2-synthesizing enzyme PIKFYVE (MIM 609414) and the PtdIns(3,5)P2 phosphatase FIG4 (MIM 609390). VAC14 functions as an activator of PIKFYVE (Sbrissa et al., 2007 [PubMed 17556371]).[supplied by OMIM, Feb 2010] Function: The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. Subcellular Location: Endosome membrane. Microsome membrane. Mainly associated with membranes of the late endocytic pathway. Tissue Specificity: Ubiquitously expressed. Similarity: Belongs to the VAC14 family. Contains 6 HEAT repeats. Database links: Entrez Gene: 55697 Human Entrez Gene: 234729 Mouse Entrez Gene: 307842 Rat Omim: 604632 Human SwissProt: Q08AM6 Human SwissProt: Q80WQ2 Mouse SwissProt: Q80W92 Rat Unigene: 445061 Human Unigene: 274894 Mouse Unigene: 46366 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
磷脂酰肌醇3，5-二磷酸（PtdIns（3，5）P2）在内体膜中的含量随着产生或吸收细胞内转运小泡的裂变和融合事件而动态变化。VAC14是紧密调节PtdIns(3,5)P2水平的三分子复合物的组成部分。该复合物的其它成分是PtdIns(3,5)P2合成酶PIKFYVE(MIM 609414)和PtdIns(3,5)P2磷酸酶FIG4(MIM 609390)。VAC14作为PIKFYVE的激活剂发挥作用(Sbrissa等人，2007[PubMed 17556371])。