RECQL5,RecQ解旋酶样蛋白5抗体

产品编号HZ-11231R
英文名称RECQL5
中文名称RecQ解旋酶样蛋白5抗体
别 名ATP-dependent DNA helicase Q5; DNA helicase, RecQ like type 5; DNA helicase, RECQ-like, type 5; RecQ helicase protein-like 5 beta; RecQ protein-like 5; RecQ protein-like 5, isoform CRA_b; RecQ5; Recq5b; Recql5b; RECQ5_HUMAN.
说 明 书0.1ml 0.2ml
研究领域染色质和核信号 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse,
RECQL5,RecQ解旋酶样蛋白5抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量109kDa
细胞定位细胞核 细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human RECQL5
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
RECQL5,RecQ解旋酶样蛋白5抗体PubMedPubMed
产品介绍background:
RecQ helicases are implicated in DNA recombination and repair helicases and are critical in genome maintenance. RecQL5 is one of five known RecQ homologues in humans, and defects in three of these (BLM, WRN and RecQ4)are associated with autosomal recessive disorders that involve genomic instability and a predisposition to cancer. The exact role of ReqL5 is unclear. It has been shown in mouse embryonic stem (ES) cells that mutations in the Recql5 genes result in a significant increase in the frequency of sister chromatid exchange (SCE), whereas deleting Recql5 lead to an even higher frequency of SCE. There are three different RecQL5 isoforms - alpha, beta and gamma, produced by alternative splicing.

Function:
May have an important role in DNA metabolism.

Subunit:
Interacts with TOP3A and TOP3B.

Subcellular Location:
Cytoplasmic and Nuclear, depending on the isoform.

Tissue Specificity:
Ubiquitous

Similarity:
Belongs to the helicase family. RecQ subfamily.
Contains 1 helicase ATP-binding domain.
Contains 1 helicase C-terminal domain.

Gene ID:
9400

Database links:
Entrez Gene: 483317 Dog
Entrez Gene: 9400 Human
Entrez Gene: 287834 Rat
Omim: 603781 Human
SwissProt: O94762 Human
Unigene: 632229 Human
Unigene: 198916 Rat

RECQL5,RecQ解旋酶样蛋白5抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.