FITC标记的多通道膜蛋白PTCHD2抗体
产品名称： FITC标记的多通道膜蛋白PTCHD2抗体
英文名称： Anti-PTCHD2/FITC
产品编号： HZ-12324R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-PTCHD2/FITC Conjugated antibody
FITC标记的多通道膜蛋白PTCHD2抗体
| 英文名称 | Anti-PTCHD2/FITC |
| 中文名称 | FITC标记的多通道膜蛋白PTCHD2抗体 |
| 别 名 | DISP3; Dispatched, drosophila, homolog of, 3; G630052C06Rik; hCG_24779; KIAA1337; Patched domain-containing protein 2; Protein dispatched homolog 3; Ptchd2; PTHD2_HUMAN; RGD1305820; RND-type protein RNDEu-2; RNDEu-2; patched domain containing 2; RP23-157B15.1; PTCHD2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 心血管 细胞生物 神经生物学 信号转导 通道蛋白 新陈代谢 细胞膜蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 153 kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from Human PTCHD2/DISP3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: PTCHD2 is a 1,392 amino acid multi-pass membrane protein that contains one SSD (sterol-sensing) domain and belongs to the patched family. Expressed in retina, brain and testis, PTCHD2 localizes to endoplasmic reticulum and colocalizes with cholesterol. PTCHD2 overexpression leads to increased cholesterol levels, suggesting that PTCHD2 may play a role in cholesterol homeostasis. PTCHD2 is further hypothesized to act as a link between thyroid hormone and cholesterol metabolism. Existing as two alternatively spliced isoforms, PTCHD2 is thought to assist in the release of lipid-anchored secreted proteins and is encoded by a gene that maps to human chromosome 1p36.22. Subcellular Location: Membrane; Multi-pass membrane protein (Potential). Tissue Specificity: Expressed in brain and testis. Similarity: Belongs to the patched family. Contains 1 SSD (sterol-sensing) domain. Database links: Entrez Gene: 57540 Human Omim: 611251 Human SwissProt: Q9P2K9 Human Unigene: 202355 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
PTCHD2是一个1392氨基酸的多程膜蛋白，含有一个SSD（甾醇敏感）结构域，属于补丁家族。在视网膜、大脑和睾丸中表达，PTCHD2定位于内质网并与胆固醇共定位。PTCHD2过表达导致胆固醇水平升高，提示PTCHD2可能在胆固醇稳态中起作用。PTCHD2还被假设为甲状腺激素和胆固醇代谢之间的联系。PTCHD2作为两种可选择的剪接异构体存在，被认为有助于脂质锚定分泌蛋白的释放，并且由映射到人类染色体1p36.22的基因编码。